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Nadroparin


Mechanism of action:

Nadroparin is a low molecular weight heparin. Nadroparin binds to antithrombin III and enhances its inhibitory effect on factor Xa, preventing factor Xa from promoting thrombin generation, that is, reducing the efficiency of converting prothrombin into thrombin. This blocks subsequent fibrin formation and prevents thrombosis.

Reference(s):

1. Collignon F et al. (1995). Comparison of the pharmacokinetic profiles of three low molecular mass heparins--dalteparin, enoxaparin and nadroparin--administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism). Thromb Haemost. 


2. Frydman A et al. (1996). Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis. 


3. Lai KN et al. (1996). Use of low-dose low molecular weight heparin in hemodialysis. Am J Kidney Dis.

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