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The Sound of Evolution
Nalbuphine
Mechanism of action:
Nalbuphine is an opioid drug. Nalbuphine acts as an agonist of the κ-opioid receptor, and activation of the κ-opioid receptor can suppress pain signal transmission in the dorsal horn of the spinal cord. Nalbuphine also antagonizes the μ-opioid receptor, so its analgesic effect does not depend on the μ receptor.
Reference(s):
Gear RW et al. (1999). The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain.
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