The Sound of Evolution
Nebivolol
Mechanism of action:
Nebivolol is a third-generation selective β₁-blocker. Nebivolol selectively blocks cardiac β₁ receptors, reducing cardiac contractility, lowering blood pressure, and decreasing cardiac workload. Nebivolol can also activate endothelial nitric oxide synthase in vascular endothelial cells, increasing nitric oxide production and causing dilation of arteries and microvessels, thereby reducing peripheral resistance.
Reference(s):
1. Gielen W et al. (2006). Nebivolol: a review of its clinical and pharmacological characteristics. Int J Clin Pharmacol Ther.
2. De Cree J et al. (1990). Comparison of the subacute hemodynamic effects of atenolol, propranolol, pindolol, and nebivolol. Angiology.
3. Van de Water A et al. (1988). Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist. J Cardiovasc Pharmacol.