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The Sound of Evolution
Neomycin
Mechanism of action:
Neomycin is an aminoglycoside antibiotic. Neomycin irreversibly binds to the 30S ribosomal subunit and disrupts the correct reading of mRNA, causing incorrect amino acids to be incorporated into proteins and producing abnormal or nonfunctional proteins.
Reference(s):
1. Lechevalier HA et al. (1975). The 25 years of neomycin. CRC Crit Rev Microbiol.
2. Macdonald RH et al. (1983). Neomycin: a review with particular reference to dermatological usage. Clin Exp Dermatol.
3. Dlugosz M et al. (2009). Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B.
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