The Sound of Evolution
Neostigmine
Mechanism of action:
Neostigmine is an acetylcholinesterase inhibitor and a quaternary ammonium carbamate derivative. Neostigmine reversibly carbamylates acetylcholinesterase, inhibiting the enzyme's activity and preventing it from breaking down acetylcholine. This leads to an increased concentration of acetylcholine in the synaptic cleft and enhances signal transmission at the neuromuscular junction.
Reference(s):
1. Trevisani GT et al. (2000). Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Dis Colon Rectum.
2. Naves LA et al. (2001). Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. J Physiol.
3. Takeuchi K et al. (2000). Stimulation by nizatidine, a histamine H(2)-receptor antagonist, of duodenal HCO(3)(-) secretion in rats: relation to anti-cholinesterase activity. World J Gastroenterol.