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The Sound of Evolution
Nevirapine
Mechanism of action:
Nevirapine is a non-nucleoside reverse transcriptase inhibitor. Nevirapine binds to an allosteric site on the HIV reverse transcriptase enzyme, causing a conformational change that abolishes its enzymatic activity and prevents the reverse transcription of viral RNA.
Reference(s):
1. Ambrose Z et al. (2009). The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J Virol.
2. Nikolenko GN et al. (2010). A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. J Virol.
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