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The Sound of Evolution
Niclosamide
Mechanism of action:
Niclosamide is a salicylanilide derivative. Although its detailed mechanism is not fully understood, it is known to inhibit mitochondrial oxidative phosphorylation in parasites, preventing ATP production. This rapidly depletes cellular energy, greatly reducing parasite motility and ultimately causing death.
Reference(s):
Thomson Micromedex et al. (2007). Advice for the Patient Volume II (27th ed.). PDR Network, LLC.
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