top of page
The Sound of Evolution
Nilutamide
Mechanism of action:
Nilutamide is a non-steroidal antiandrogen. Its main action is to block androgen receptor function, preventing receptor activation and thereby suppressing the expression of genes involved in growth promotion, anti-apoptosis, metabolism, differentiation, invasion, and metastasis.
Reference(s):
1. Kassouf W et al. (2003). Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J Urol.
2. Lukka H et al. (2006). Maximal androgen blockade for the treatment of metastatic prostate cancer--a systematic review. Curr Oncol.
bottom of page