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The Sound of Evolution
Nimodipine
Mechanism of action:
Nimodipine is a calcium channel blocker and a dihydropyridine derivative with high cerebrovascular selectivity. Nimodipine primarily acts on cerebral vascular smooth muscle cells by blocking L-type calcium channels, reducing calcium influx into the cytoplasm and causing vascular smooth muscle relaxation.
Reference(s):
1. Janjua N et al. (2003). Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care.
2. Allen GS et al. (1983). Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med.
3. Belfort MA et al. (2003). A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med.
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