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The Sound of Evolution
Nisoldipine
Mechanism of action:
Nisoldipine is a calcium channel blocker and a dihydropyridine derivative. Nisoldipine primarily acts on vascular smooth muscle cells by blocking L-type calcium channels, reducing calcium influx into the cytoplasm. This causes vascular smooth muscle relaxation and lowers blood pressure.
Reference(s):
1. Mielcarek J et al. (2005). The effect of beta-carotene on the photostability of nisoldipine. Methods Find Exp Clin Pharmacol.
2. Missan S et al. (2003). Block of cardiac delayed-rectifier and inward-rectifier K⁺ currents by nisoldipine. Br J Pharmacol.
3. Hamilton SF et al. (1999). Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure. Heart Dis.
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