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The Sound of Evolution
Nitrofurantoin
Mechanism of action:
Nitrofurantoin is a nitrofuran derivative. After entering bacteria, nitrofurantoin is reduced by bacterial nitroreductases, generating highly reactive intermediates. These intermediates simultaneously attack bacterial DNA, RNA, proteins, and cell membranes, causing multi-layered cellular damage.
Reference(s):
1. Mannisto PT et al. (1982). Nitrofurantoin is highly bound to plasma protein. J Antimicrob Chemother.
2. McOsker CC et al. (1994). Nitrofurantoin: mechanism of action and implications for resistance development in common uropathogens. J Antimicrob Chemother.
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