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The Sound of Evolution
Nitrous oxide
Mechanism of action:
Nitrous oxide does not act through a single receptor, but rather through multiple central nervous system regulatory mechanisms. Among these, nitrous oxide inhibits NMDA receptors, thereby reducing glutamatergic excitatory neurotransmission. Nitrous oxide also activates the μ-opioid receptor and increases the release of endorphins and enkephalins.
Reference(s):
Orestes P et al. (2011). Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol.
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