The Sound of Evolution
Nizatidine
Mechanism of action:
Nizatidine is a histamine H₂-receptor antagonist. Under normal conditions, histamine binds to the H₂ receptor and activates adenylyl cyclase, leading to an increase in cAMP and subsequent stimulation of the H⁺/K⁺-ATPase proton pump to secrete gastric acid. Nizatidine competitively antagonizes the H₂ receptor and inhibits this mechanism.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Enriz RD et al. (1991). [Theoretical conformation study of tiotidine and nizatidine, two strong histamine H2-receptor antagonists]. Acta Cient Venez.
3. Meredith CG et al. (1985). Nizatidine, a new histamine H2-receptor antagonist, and hepatic oxidative drug metabolism in the rat: a comparison with structurally related compounds. Toxicol Appl Pharmacol.