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The Sound of Evolution
Nortriptyline
Mechanism of action:
Nortriptyline is a tricyclic antidepressant. Nortriptyline inhibits the norepinephrine transporter primarily and the serotonin transporter secondarily, preventing the reuptake of norepinephrine and serotonin (5-HT). As a result, their concentrations in the synaptic cleft increase, enhancing the actions of these neurotransmitters.
Reference(s):
1. Prochazka AV et al. (1998). A randomized trial of nortriptyline for smoking cessation. Arch Intern Med.
2. Nelson JC et al. (1999). Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease. Am J Psychiatry.
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