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The Sound of Evolution
Nystatin
Mechanism of action:
Nystatin is a polyene antifungal agent that preferentially binds to ergosterol in the fungal cell membrane, forming transmembrane pores that lead to osmotic imbalance, leakage of cellular contents, and cell death.
Reference(s):
1. Akaike N et al. (1994). Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol.
2. Dos Santos AG et al. (2017). The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition. Phys Chem Chem Phys.
3. Karlgren M et al. (2012). Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem.
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