The Sound of Evolution
Octreotide
Mechanism of action:
Octreotide is a synthetic somatostatin analog and a cyclic octapeptide. Octreotide activates somatostatin receptors, with the highest affinity for SSTR2 and SSTR5. Once somatostatin receptors are activated, adenylyl cyclase is inhibited, cAMP levels decrease, and the release of hormones such as growth hormone, insulin, glucagon, gastrin, and secretin is suppressed.
Reference(s):
1. Biermasz NR et al. (2017). New medical therapies on the horizon: oral octreotide. Pituitary.
2. Battershill PE et al. (1989). Octreotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in conditions associated with excessive peptide secretion. Drugs.
3. Prelevic GM et al. (1990). Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome. Lancet.