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The Sound of Evolution
Ofloxacin
Mechanism of action:
Ofloxacin is a fluoroquinolone antibiotic. Ofloxacin inhibits the activity of bacterial DNA gyrase, which is bacterial topoisomerase II, as well as topoisomerase IV. This interferes with DNA replication, transcription, repair, and segregation, ultimately causing bacterial death.
Reference(s):
1. Schmitz FJ et al. (1998). Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother.
2. Cambau E et al. (1994). Selection of a gyrA mutant of Mycobacterium tuberculosis resistant to fluoroquinolones during treatment with ofloxacin. J Infect Dis.
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