The Sound of Evolution
Olopatadine
Mechanism of action:
Olopatadine is a second-generation H1 antihistamine. Olopatadine competitively antagonizes H1 receptors, blocking histamine-induced vasodilation, increased vascular permeability, and sensory nerve stimulation. It also inhibits mast cell degranulation, thereby reducing the release of histamine, leukotrienes, platelet-activating factor (PAF), and other mediators.
Reference(s):
1. Ohmori K et al. (2002). Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol.
2. Ohmori K et al. (2004). Properties of olopatadine hydrochloride, a new antiallergic/antihistaminic drug. Arzneimittelforschung.
3. Rosenwasser LJ et al. (2005). Mast cell stabilization and anti-histamine effects of olopatadine ophthalmic solution: a review of pre-clinical and clinical research. Curr Med Res Opin.