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The Sound of Evolution
Olsalazine
Mechanism of action:
Olsalazine is a prodrug of 5-aminosalicylic acid. After being converted into 5-aminosalicylic acid in the colon, it exerts its pharmacological effects. 5-Aminosalicylic acid inhibits cyclooxygenase and lipoxygenase, reducing the production of prostaglandins and leukotrienes and thereby decreasing intestinal inflammation.
Reference(s):
1. Wadworth AN et al. (1991). Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs.
2. Campbell DE et al. (1988). Pharmacology of olsalazine. Scand J Gastroenterol Suppl.
3. Horn H et al. (1991). Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol.
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