The Sound of Evolution
Omeprazole
Mechanism of action:
Omeprazole is a proton pump inhibitor and a racemic mixture of R and S isomers. In the stomach, omeprazole is activated into a sulfenamide form, which then forms covalent bonds with the H+/K+-ATPase proton pump in gastric parietal cells, irreversibly inhibiting its activity and blocking the secretion of hydrogen ions into the gastric lumen.
Reference(s):
1. Yang YX et al. (2006). Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA.
2. Castell D et al. (2005). Review of immediate-release omeprazole for the treatment of gastric acid-related disorders. Expert Opin Pharmacother.
3. Higuera-de-la-Tijera F et al. (2018). Efficacy of omeprazole/sodium bicarbonate treatment in gastroesophageal reflux disease: a systematic review. Medwave.