The Sound of Evolution
Oprelvekin
Mechanism of action:
Oprelvekin is a recombinant human interleukin-11. Oprelvekin binds to IL-11 receptor alpha (IL-11Ralpha) on megakaryocyte progenitor cells and then recruits the gp130 co-receptor to form a signaling complex. This activates the JAK1/JAK2 pathway, leading to phosphorylation of STAT3, which enters the nucleus and induces the expression of hematopoiesis-related genes. As a result, megakaryocyte progenitor cells proliferate, differentiate, and mature, promoting platelet production.
Reference(s):
1. Nandurkar HH et al. (1998). The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor. Stem Cells.
2. Li R et al. (2001). Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Reproduction.
3. Nandurkar HH et al. (1996). The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor. Oncogene.