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The Sound of Evolution
Oseltamivir
Mechanism of action:
Oseltamivir is a neuraminidase inhibitor. Oseltamivir is a prodrug that is converted by esterases in the liver into the active metabolite oseltamivir carboxylate. This active metabolite inhibits neuraminidase (NA) on the surface of influenza viruses, preventing viral particles from being released from infected cells.
Reference(s):
1. Chokephaibulkit K et al. (2005). A child with avian influenza A (H5N1) infection. Pediatr Infect Dis J.
2. de Jong MD et al. (2005). Oseltamivir resistance during treatment of influenza A (H5N1) infection. N Engl J Med.
3. Kiso M et al. (2004). Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet.
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