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The Sound of Evolution
Oxaliplatin
Mechanism of action:
Oxaliplatin is a third-generation platinum compound. After oxaliplatin enters the cell, the oxalate group dissociates, leaving behind a highly reactive platinum ion intermediate. The active platinum binds to the N7 position of guanine in DNA, forming intrastrand and interstrand crosslinks. These lesions distort the double-stranded DNA structure, thereby inhibiting DNA replication and transcription and ultimately triggering apoptosis.
Reference(s):
1. Pasetto LM et al. (2006). Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol.
2. Graham J et al. (2004). Oxaliplatin. Nat Rev Drug Discov.
3. Alcindor T et al. (2011). Oxaliplatin: a review in the era of molecularly targeted therapy. Curr Oncol.
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