The Sound of Evolution
Oxazepam
Mechanism of action:
Oxazepam is a benzodiazepine derivative. Oxazepam binds to the benzodiazepine binding site on GABA_A receptors in the central nervous system, enhancing GABAergic inhibitory activity. When GABA binds to these receptors, chloride (Cl-) channels open, causing neuronal membrane hyperpolarization and reducing neuronal excitability, thereby decreasing excessive activation in the limbic system and cerebral cortex.
Reference(s):
1. Peppers MP et al. (1996). Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease. Pharmacotherapy.
2. Skerritt JH et al. (1983). Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol.
3. Oelschlager H et al. (1989). [Chemical and pharmacologic aspects of benzodiazepines]. Schweiz Rundsch Med Prax.