The Sound of Evolution
Oxybutynin
Mechanism of action:
Oxybutynin is a muscarinic acetylcholine receptor inhibitor that mainly antagonizes M3 receptors, with M1 and M2 being secondary targets. Under normal conditions, activation of M3 receptors increases IP3/Ca2+ through Gq proteins and promotes bladder contraction. By inhibiting M3 receptors, oxybutynin relaxes the detrusor muscle.
Reference(s):
1. Douchamps J et al. (1988). The pharmacokinetics of oxybutynin in man. Eur J Clin Pharmacol.
2. Kennelly MJ et al. (2010). A comparative review of oxybutynin chloride formulations: pharmacokinetics and therapeutic efficacy in overactive bladder. Rev Urol.
3. Yarker YE et al. (1995). Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging.