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The Sound of Evolution
Panobinostat
Mechanism of action:
Panobinostat is a histone deacetylase inhibitor and a hydroxamic acid derivative. Under normal conditions, histone deacetylases remove acetyl groups from histones, causing chromatin condensation and suppression of gene transcription. Panobinostat inhibits class I, II, and IV histone deacetylases, increasing histone acetylation and loosening chromatin structure, which allows previously suppressed tumor suppressor genes to be re-expressed.
Reference(s):
1. Qian DZ et al. (2006). Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589. Clin Cancer Res.
2. Laubach JP et al. (2015). Panobinostat for the Treatment of Multiple Myeloma. Clin Cancer Res.
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