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Pantoprazole


Mechanism of action:

Pantoprazole is a proton pump inhibitor and a benzimidazole derivative. Pantoprazole is a prodrug that is converted into its active sulfenamide form within the acidic secretory canaliculi of gastric parietal cells. The sulfenamide forms a covalent bond with the H+/K+-ATPase proton pump, irreversibly inhibiting proton extrusion and blocking gastric acid secretion.

Reference(s):

1. Mathews S et al. (2010). An update on the use of pantoprazole as a treatment for gastroesophageal reflux disease. Clin Exp Gastroenterol. 


2. Dabrowski A et al. (2018). Meta-analysis of the efficacy and safety of pantoprazole in the treatment and symptom relief of patients with gastroesophageal reflux disease - PAN-STAR. Prz Gastroenterol. 


3. Strand DS et al. (2017). 25 Years of Proton Pump Inhibitors: A Comprehensive Review. Gut Liver.

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