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The Sound of Evolution
Pazopanib
Mechanism of action:
Pazopanib is a multi-target receptor tyrosine kinase inhibitor. Pazopanib binds to the ATP-binding sites of receptor tyrosine kinases such as VEGFR-1/2/3 and PDGFR-α/β, blocking receptor autophosphorylation and downstream signaling pathways, including PI3K-AKT-mTOR and RAS-RAF-MEK-ERK. As a result, it inhibits tumor angiogenesis and tumor growth.
Reference(s):
1. Sonpavde G et al. (2008). Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Expert Opin Investig Drugs.
2. Verweij J et al. (2013). Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother.
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