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The Sound of Evolution
Pegfilgrastim
Mechanism of action:
Pegfilgrastim is a synthetic granulocyte colony-stimulating factor, or G-CSF. Pegfilgrastim binds to the G-CSF receptor on neutrophils and activates pathways such as JAK-STAT, PI3K-AKT, and MAPK/ERK, significantly increasing both the rate and number of neutrophil production.
Reference(s):
1. Yang BB et al. (2011). Pharmacokinetics and pharmacodynamics of pegfilgrastim. Clin Pharmacokinet.
2. Curran MP et al. (2002). Pegfilgrastim. Drugs.
3. Molineux G et al. (2004). The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des.
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