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The Sound of Evolution
Pemetrexed
Mechanism of action:
Pemetrexed is a multitarget antifolate. After entering the cell, pemetrexed is converted into its polyglutamated form, polyglutamated pemetrexed, which inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. This disrupts purine and pyrimidine synthesis, preventing cells from carrying out normal DNA and RNA synthesis.
Reference(s):
1. Rollins KD et al. (2005). Pemetrexed: a multitargeted antifolate. Clin Ther.
2. Lansiaux A et al. (2007). [Pemetrexed: from preclinic to clinic]. Bull Cancer.
3. Fuld AD et al. (2010). Pemetrexed in advanced non-small-cell lung cancer. Expert Opin Pharmacother.
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