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The Sound of Evolution
Penciclovir
Mechanism of action:
Penciclovir is a nucleoside analog. Inside cells, Penciclovir is converted into the active form penciclovir triphosphate, which competes with dGTP and selectively inhibits viral DNA polymerase, thereby preventing effective viral replication.
Reference(s):
1. Scott GM et al. (2005). Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. J Gen Virol.
2. Agut H et al. (2009). Testing the susceptibility of human herpesviruses to antivirals. Future Microbiol.
3. Deval J et al. (2009). Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs.
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