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The Sound of Evolution
Pentamidine
Mechanism of action:
Pentamidine is an aromatic diamidine compound. Pentamidine has a positively charged diamidine structure that can selectively bind AT-rich sequences in the DNA of organisms such as Trypanosoma brucei and Pneumocystis jirovecii, interfering with DNA replication and transcription and inhibiting RNA and protein synthesis. Pentamidine also disrupts the mitochondrial membrane potential, inhibits oxidative phosphorylation, and reduces ATP production.
Reference(s):
Nguewa PA et al. (2005). Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers.
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