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The Sound of Evolution
Pentobarbital
Mechanism of action:
Pentobarbital is a barbiturate derivative. Pentobarbital binds to the barbiturate binding site on the GABA_A receptor complex, prolonging the opening time of chloride channels and increasing Cl⁻ influx. This causes neuronal hyperpolarization and reduces neuronal excitability, producing sedative and relaxing effects and influencing central nervous system regulation associated with tension headaches.
Reference(s):
Knodell RG et al. (1980). Alterations in pentobarbital pharmacokinetics in response to parenteral and enteral alimentation in the rat. Gastroenterology.
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