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Pentostatin


Mechanism of action:

Pentostatin is an adenosine deaminase inhibitor. Adenosine deaminase is responsible for deaminating deoxyadenosine and maintaining purine metabolic balance. After Pentostatin inhibits adenosine deaminase, deoxyadenosine accumulates within cells, and intracellular dATP increases markedly. Excess dATP inhibits the activity of ribonucleotide reductase, resulting in a relative deficiency of dTTP, dCTP, and dGTP and thereby impairing DNA synthesis.

Reference(s):

1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res. 


2. Jackson RC et al. (1986). The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase. Adv Enzyme Regul. 


3. Newman DJ et al. (2007). Natural products as sources of new drugs over the last 25 years. J Nat Prod.

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