The Sound of Evolution
Perindopril
Mechanism of action:
Perindopril is an angiotensin-converting enzyme inhibitor and a dipeptide prodrug. In the body, Perindopril is converted into the active form perindoprilat. Perindoprilat inhibits angiotensin-converting enzyme, which normally converts angiotensin I into angiotensin II, thereby reducing peripheral vascular resistance and lowering blood pressure.
Reference(s):
1. Hurst M et al. (2001). Perindopril: an updated review of its use in hypertension. Drugs.
2. Jastrzebskal M et al. (2004). Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin converting enzyme (ACE) and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms. Nutr Metab Cardiovasc Dis.
3. Parker E et al. (2005). The pharmacokinetics of perindoprilat in normal volunteers and patients: influence of age and disease state. Eur J Pharm Sci.