The Sound of Evolution
Perphenazine
Mechanism of action:
Perphenazine is a phenothiazine derivative. Perphenazine antagonizes D₂ receptors in the mesolimbic pathway, reducing excessive dopamine activity and thereby decreasing hallucinations, delusions, and disorganized thinking. It also inhibits D₂ receptors in the mesocortical pathway, which may affect certain cognitive functions as well as emotional and motivational processes.
Reference(s):
1. Seeman P et al. (2002). Atypical antipsychotics: mechanism of action. Can J Psychiatry.
2. Hoyberg OJ et al. (1993). Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand.
3. Qin ZH et al. (1994). Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra. Eur J Pharmacol.