The Sound of Evolution
Phenazopyridine
Mechanism of action:
Phenazopyridine is an azo dye derivative. The exact mechanism of action of Phenazopyridine has not been fully clarified, but it is known that after renal excretion, it reduces sensory nerve stimulation and pain perception on the surface of the bladder and urethral mucosa, thereby decreasing the sensitivity of the urinary tract mucosa to mechanical and chemical stimulation during urination under inflammatory or irritated conditions.
Reference(s):
1. Shore SN et al. (2019). Safety analysis of long-term phenazopyridine use for radiation cystitis. J Oncol Pharm Pract.
2. Suter DM et al. (2009). Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells. J Cell Mol Med.
3. Rehfuss A et al. (2018). Phenazopyridine: A Preoperative Way to Identify Ureteral Orifices. Urology.