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The Sound of Evolution
Phenindamine
Mechanism of action:
Phenindamine is a first-generation H₁ antihistamine and an ethylenediamine derivative. Phenindamine binds to the histamine H₁ receptor and prevents histamine from acting on it, thereby reducing histamine-induced vasodilation, capillary leakage, nasal mucosal edema, and itching.
Reference(s):
1. ter Laak AM et al. (1995). The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem.
2. Witek TJ Jr et al. (1992). The effects of phenindamine tartrate on sleepiness and psychomotor performance. J Allergy Clin Immunol.
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