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Phenoxybenzamine


Mechanism of action:

Phenoxybenzamine is an irreversible α-adrenergic blocker. It blocks α₁ receptors on vascular smooth muscle, causing peripheral vasodilation and lowering blood pressure. It also blocks neuronal α₂ receptors, promoting norepinephrine release and potentially causing reflex tachycardia.

Reference(s):

1. Caine M et al. (1978). A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction. Br J Urol. 


2. Frang H et al. (2001). Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors. J Biol Chem.

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