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The Sound of Evolution
Phentolamine
Mechanism of action:
Phentolamine is a reversible, non-selective α-adrenergic blocker. It blocks α₁ receptors on vascular smooth muscle, causing peripheral vasodilation and lowering blood pressure. At neuronal α₂ receptors, it promotes norepinephrine release and can induce reflex tachycardia.
Reference(s):
1. Gould L et al. (1976). Phentolamine. Am Heart J.
2. Raja SN et al. (1991). Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain. Anesthesiology.
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