The Sound of Evolution
Pioglitazone
Mechanism of action:
Pioglitazone is an insulin sensitizer and a thiazolidinedione derivative. It binds to the transcription factor PPAR-γ within the nuclei of cells in adipose tissue, liver, and skeletal muscle. The resulting complex then binds to the PPAR response element in DNA and, through gene regulation, increases the responsiveness of adipocytes to insulin, promotes redistribution of free fatty acids into adipose tissue, and reduces free fatty acid-induced insulin resistance in the liver and skeletal muscle.
Reference(s):
1. Al-Majed A et al. (2016). Pioglitazone. Profiles Drug Subst Excip Relat Methodol.
2. Janani C et al. (2015). PPAR gamma gene--a review. Diabetes Metab Syndr.
3. Zhou SF et al. (2009). Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem.