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The Sound of Evolution
Pirbuterol
Mechanism of action:
Pirbuterol is a selective β₂-adrenergic agonist. It activates β₂ receptors on bronchial smooth muscle and, through Gs protein coupling, activates adenylate cyclase, increasing cAMP levels and subsequently activating protein kinase A. This ultimately relaxes bronchial smooth muscle and produces bronchodilation.
Reference(s):
1. Carie AE et al. (2007). A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene.
2. Leier CV et al. (1982). Intravenous pirbuterol. Clin Pharmacol Ther.
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