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The Sound of Evolution
Piroxicam
Mechanism of action:
Piroxicam is an oxicam derivative. It inhibits cyclooxygenase, including both COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Blanco FJ et al. (1999). Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol.
2. Bugajski J et al. (2001). Involvement of constitutive (COX-1) and inducible cyclooxygenase (COX-2) in the adrenergic-induced ACTH and corticosterone secretion. J Physiol Pharmacol.
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