The Sound of Evolution
Prednisolone
Mechanism of action:
Prednisolone is a synthetic glucocorticoid. Prednisolone is a lipophilic molecule that freely crosses the cell membrane and binds to the glucocorticoid receptor in the cytoplasm. This forms a ligand-receptor complex that then translocates into the nucleus, where it upregulates the expression of anti-inflammatory genes such as annexin A1 and suppresses the expression of pro-inflammatory genes such as IL-1, IL-2, IL-6, and TNF-alpha.
Reference(s):
1. Pickup ME et al. (1979). Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet.
2. Ferry JJ et al. (1988). Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses. J Clin Pharmacol.
3. Matabosch X et al. (2015). Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom.