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The Sound of Evolution
Probenecid
Mechanism of action:
Probenecid is a uricosuric agent. Probenecid mainly inhibits urate transporter 1 (URAT1) and organic anion transporter 4 (OAT4) in proximal renal tubular epithelial cells, reducing the reabsorption of uric acid from the tubular lumen back into the blood. This increases uric acid excretion and lowers serum uric acid levels.
Reference(s):
Butler D et al. (2005). Wartime tactic doubles power of scarce bird-flu drug. Nature.
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