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The Sound of Evolution
Procarbazine
Mechanism of action:
Procarbazine is a compound with alkylating reactivity. After entering the body, procarbazine is metabolized by enzymes in the liver and tumor cells into highly reactive free radicals and methyl donors. Its active metabolites methylate DNA, especially guanine residues, induce single-strand and double-strand DNA breaks, interfere with DNA replication and transcription, and ultimately trigger apoptosis.
Reference(s):
1. Holt A et al. (1992). Characteristics of procarbazine as an inhibitor in-vitro of rat semicarbazide-sensitive amine oxidase. J Pharm Pharmacol.
2. Kraft SL et al. (2014). Procarbazine and antidepressants: a retrospective review of the risk of serotonin toxicity. Psychooncology.
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