The Sound of Evolution
Procaterol
Mechanism of action:
Procaterol is a bronchodilator and a selective beta2-adrenergic receptor agonist. After binding to beta2 receptors on bronchial smooth muscle cell membranes, procaterol activates Gs protein, which in turn stimulates adenylyl cyclase, increases cAMP, activates protein kinase A, and inhibits myosin light chain kinase (MLCK), ultimately leading to relaxation of bronchial smooth muscle.
Reference(s):
1. Kobayashi M et al. (2002). [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]. Nihon Kokyuki Gakkai Zasshi.
2. Yamasaki Y et al. (2004). [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance]. Nihon Kokyuki Gakkai Zasshi.