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The Sound of Evolution
Prochlorperazine
Mechanism of action:
Prochlorperazine is a phenothiazine derivative. Prochlorperazine mainly antagonizes D2 receptors in the chemoreceptor trigger zone (CTZ) of the medulla, thereby suppressing initiation of the vomiting reflex.
Reference(s):
1. Isah AO et al. (1991). Clinical pharmacology of prochlorperazine in healthy young males. Br J Clin Pharmacol.
2. Isah AO et al. (1992). The pharmacokinetics and effects of prochlorperazine in elderly female volunteers. Age Ageing.
3. Perwitasari DA et al. (2011). Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics. Int J Clin Pharm.
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