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Progesterone


Mechanism of action:

Progesterone is a steroid hormone and a lipophilic molecule that freely crosses the cell membrane. In the cytoplasm, it binds to progesterone receptors, including PR-A and PR-B, forming a complex that then enters the nucleus and binds to progesterone response elements in DNA, thereby regulating the expression of reproduction-related genes.

Reference(s):

1. Schumacher M et al. (2004). Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 


2. Hould FS et al. (1988). Progesterone receptors regulate gallbladder motility. J Surg Res. 


3. Payne VA et al. (1999). Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes. Proteins.

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