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The Sound of Evolution
Proguanil
Mechanism of action:
Proguanil is a biguanide derivative. In the liver, proguanil is metabolized by CYP2C19 into the active compound cycloguanil. Cycloguanil selectively inhibits dihydrofolate reductase in Plasmodium, blocks the folate metabolic cycle, and thereby suppresses purine and pyrimidine synthesis, resulting in impaired DNA and RNA synthesis.
Reference(s):
Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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